Background: Carpal Tunnel Syndrome (CTS) is the most common form of median nerve entrapment, and represents about 90% of all entrapment neuropathies. Diagnosis of CTS depends mainly on clinical evaluation and nerve conduction studies. This study aims at studying sensitivities of different conventional and other modified neurophysiological methods in the diagnosis of carpal tunnel syndrome. Methods: One hundred and nine hands of 83 patients with clinical presentation of CTS have been included in this study in the period between August, 2022 and February, 2023. Hands were classified clinically as mild to moderate or severe according to the modified criteria of the Italian CTS Study Group. Conventional techniques used were assessment of the median nerve distal motor latency at wrist and assessment of the median nerve sensory conduction velocity at index. We used also 2 motor and 6 sensory modified techniques. Results: Collectively, modified nonconventional techniques - especially the sensory ones - showed higher sensitivities than those of conventional techniques. Differences were more obvious in patients with mild to moderate clinical presentation. The most sensitive methods were methods measuring differences between median and ulnar sensory latencies. Conclusion: Sensory modified techniques were the most helpful in diagnosing CTS especially in patients with early clinical presentation