Cryptosporidium is a protozoan parasite that cause diarrhea with significant morbidity and mortality. Few antiparasitic drugs are effective against it. Therefore, finding an alternative is necessary. The current study aimed to evaluate the therapeutic efficacy of ginger (Zingiber officinale) in experimentally infected mice. Mice were divided into five groups: G1: healthy controls, G2: infected/untreated, G3: infected/ginger-treated, G4: infected/nitazoxanide-treated and G5: uninfected/ginger-treated. On day 7 post-inoculation, each group started its specific treatment. Diarrhea, weight, daily oocyst shedding, serum levels of IL12, IFNγ, TNFα, IL10, and IL4 levels were recorded. Furthermore, ileal histopathology was done. The mean weight gain of G3 and G4 mice was significantly higher than that in G2 (P< 0.001). Oocyst shedding was significantly reduced in G3 and G4 by day 10 pi (P< 0.02), till zero by day 20 pi. On day 10, IFNγ, TNFα and IL12 were significantly lower in G3 and G4 than that in G2. On day 21, G2 showed a significant upregulation of TNFα compared to that in G3 and G4. Both G3 and G4 showed upregulation of IL4 vs. G2 (p value < 0.0001). The histological architecture of villi in G3 and G4 showed visible improvement compared to that in G2. These results suggest that ginger is a promising anti-cryptosporidium treatment without side effects.