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320970

Pattern of Breast Cancer in Young Females in Minia Governorate.

Article

Last updated: 28 Dec 2024

Subjects

-

Tags

Cancer research.
Healthcare research

Abstract

Background: Breast cancer is the most common cause of cancer in women worldwide. Although it is a disease of postmenopausal and elderly age group, approximately 5.6% of breast cancer patients are ≤40 years. It has aggressive clinical behavior with poor outcomes as compared to the elderly group. This study was carried out to determine the pattern of breast cancer in young females in Minia district. Methods: This is a retrospective cohort study collecting data in Minia university hospital and Minia oncology center from 2017 to 2021, for patients with primary breast cancer who were diagnosed and pathologically proven breast cancer below age of 40. Patients were staged according to TNM staging system (according to American Joint Committee on Cancer AJCC 2017) Immunohistochemistry was used for molecular classification. Results:  Total number of cases of breast cancer cases below age of 40 was 279 which represent 10% of 2760 cases. About 10.8% of patients had family history, 91% of patients presented with infiltrating ductal carcinoma and  (82.4%) had Grade II disease . About 98 (35.7%) cases were luminal A, 30.5% were luminal B. HER2 positive in 47cases (16.8%) and triple negative patients 49 cases (17.6%).   Majority of patients had negative ovulation induction, stage II 45.9%, nodal status N1 34.1% . Conclusion: The reflection of molecular subtypes on overall survival was not statistically significant but ki67 and association of primary tumor stage T and the prevalence of metastasis to lymph nodes were statistically significant.

DOI

10.21608/mjmr.2023.195769.1356

Keywords

breast cancer, young females, Survival

Authors

First Name

Amani

Last Name

Gerges

MiddleName

Saber

Affiliation

Department of Clinical Oncology, Faculty of Medicine, Minia University, Minia, Egypt

Email

amanisaber@yahoo.com

City

-

Orcid

-

First Name

Nada

Last Name

Sholkamy

MiddleName

Hussein

Affiliation

Department of Clinical Oncology, Faculty of Medicine, Minia University, Minia, Egypt

Email

nadasholkamy1984@hotmail.com

City

El Minia

Orcid

-

First Name

Ahmed

Last Name

Saleh

MiddleName

Mahmoud

Affiliation

Department of Clinical Oncology, Faculty of Medicine, Minia University, Minia, Egypt

Email

ahmedmahmoudrabea0@gmail.com

City

Minia

Orcid

-

Volume

34

Article Issue

2

Related Issue

41133

Issue Date

2023-04-01

Receive Date

2023-03-01

Publish Date

2023-04-01

Page Start

116

Page End

124

Online ISSN

2682-4558

Link

https://mjmr.journals.ekb.eg/article_320970.html

Detail API

https://mjmr.journals.ekb.eg/service?article_code=320970

Order

15

Type

Original Article

Type Code

2,212

Publication Type

Journal

Publication Title

Minia Journal of Medical Research

Publication Link

https://mjmr.journals.ekb.eg/

MainTitle

Pattern of Breast Cancer in Young Females in Minia Governorate.

Details

Type

Article

Created At

28 Dec 2024