Abstract



Background; although surgical field visualization is important in functional Endoscopic sinus surgery (FESS), the complications associated with controlled hypotension for surgery should be considered. Intraoperative hypotension (IOH) may be associated with postoperative acute kidney injury (AKI), but the duration of hypotension for triggering harm is unclear, Aim and objectives; early evaluation of acute kidney injury (AKI) following induced hypotension during FESS operation using kidney biomarker as NGAL , Subjects and methods; This prospective cohort study was conducted in anaesthsia and intensive care department in Minia University Hospital in the period from April 2021 To April 2022, after obtaining Institutional Ethical Committee approval and written informed consent from patients.

A total number of twenty male & female patients aged 18-60 years with BMI 23-27 and ASA physical status I & II who were candidate for (functional endoscopic sinus surgery) FESS under the effect of hypotensive anaesthesia, were enrolled in this prospective cohort study, Result Demographic data of the studied population (n=20), including 11 males (55%) and 9 females (45%), and mean of age of 36.50 ±10. Regarding Comparison between urea and creatinine levels by Wilcoxon Signed Ranks Test.

There was a significant difference between preoperative and 3 hour postoperative NGAL in the studied group Conclusion; NGAL is the most sensitive biomarker that can detect early acute kidney injury.