Abstract:

Immune thrombocytopenia (ITP) is an autoimmune disease characterized by low platelet counts with or without mucocutaneous bleeding. Like the majority of autoimmune diseases, ITP is an organ-specific disease and abnormalities in the regulation of immune system have been shown to play an important role in the initiation and/or perpetuation of the disease [1].

Aim of the study: The aim of this study was to investigate the demographic characteristics, comorbidities associated with chronic medications, bleeding phenotypes in primary immune thrombocytopenia patients according to the chronicity of the disease.

Patients & Methods: This current study is a cross-sectional hospital based analytic study. It was carried out at the hematology unit / internal medicine department of El- Minia University Hospital.

It was conducted on a group of patients with ITP who were admitted at the hematology unit / internal medicine department or attended the hematology outpatient clinic of El- Minia University hospital since August 2021 till September 2022.

It included 33 subjects, where clinical examination, biochemical tests, ITP bleeding score 2016, and ultrasonography were performed on them whose ages range from 16 to 73 years.



Results: Life threating bleeding is more common in acute conditions than chronic ones with higher bleeding score (p value = 0.03)

Conclusion: Chronic patients may have protective effect from life threating bleeding but higher associated comorbidities.

Keywords: ITP, Bleeding score, life threating bleeding, chronicity .