Background: Due to coronavirus's simple means of transmission, COVID-19 spread like wildfire. The use of biomarkers in emergency departments for corona virus infection screening and early diagnosis is gaining more attention. Aim and objectives: This study aimed to evaluate D-dimer, fibrinogen and p-selectin levels in hospitalized Covid-19 patients and its correlations with other routine investigations for predication of their prognosis. Subjects and methods: On 40 covid-19 patients, levels of D-dimer, fibrinogen, and soluble P-selectin in both ICU and non-ICU patients were measured and correlations with other routine investigations were done. Results: According to D-dimer, p-selectin, and fibrinogen among the groups under study, there was a statistical significance increase in D-dimer and p- selectin in both ICU(p<0.001, 0.0001) and non- ICU (p=0.014,0.0001) when compared with control. But, fibrinogen was decrease in non-ICU when compared with control group (p=0.0001) and then start to increase in ICU patients when compared with non ICU patients (p=0.029). Conclusions: All physicians are extremely concerned about the worldwide emergency of COVID-19 disease. Therefore, readily available biomarkers including D-dimer, fibrinogen, and p-selectin are useful for determining and suspecting the fate of COVID-19, particularly in patients who are hospitalised.