Objectives: To compare conventional long protocol versus Duostim protocol to improve pregnancy rate in poor responders undergoing ICSI.

Patients & methods: This prospective randomized study included fifty poor responders planned for ICSI in Minia infertility research unit (MIRU) between the period of January 2020 and Desember 2021. The participants were presented in two groups as follow: Group A: include 25 patients used the standard long protocol for controlled ovarian hyperstimulation & Group B: include 25 patients used the double stimulation protocol (Duo Stim) for controlled ovarian hyperstimulation.

Results: Our results observed that both groups were comparable as regards to their baseline characteristics. The chemical pregnancy rate was insignificantly (P= 0.306) higher in the Duostim group than the long protocol group. It was 28% in the Duostim group and 16% in the long protocol group. The clinical pregnancy rate was insignificantly (P= 0.44) higher in the Duostim group than in the long protocol group. It was 20% in the Duostim group and 12% in the long protocol group.

Conclusion: Duostim protocol is apromising protocol in poor responders