Abstract

Background:

Multiple sclerosis (MS) is an autoimmune disease that causes inflammatory demyelination in the central nervous system (CNS). The pathogenesis of MS involves interaction between a lot of factors including genetic, epigenetic and environmental factors. Many studies have focused on the role of micro-Ribonucleic acids in the pathogenesis of MS including miRNA 145 and miRNA 484.

Objectives:

The aim of this study is to evaluate the relation between the expression of micro-Ribonucleic acid 484 and the radiological features of MS patients.

Patients and Methods:

Plasma samples of 31 MS patients were analyzed using real time polymerase chain reaction technique to measure the relative expression of micro-Ribonucleic acid 484 in addition to MRI of those patients were analyzed for the number of T2 lesions in the brain and the spinal cord.

Results:

There was an insignificant positive correlation between miRNA expression and MRI T2 lesion number.

Conclusion:

miRNA -484 expression in MS patients is not significantly correlated with radiological features.