Background: COPD is a systemic inflammatory and endothelial disease, it is characterized by airflow limitation, dyspnea and exacerbations, dyspnea is a cardinal symptom of this disease, and its severity and magnitude increases as the disease progresses, leading to significant disability and a negative effect on quality of life. Objectives: This work aims to assist severity of dyspnea with progress of the disease and role of complete blood count in diagnosis of exacerbation. Methods: The blood samples were collected by aseptic way and undergo routine and specific analysis. Results: 80 % of stable COPD patients were complaining of exertional dyspnea while 85 % of COPD patients suffered from dyspnea at rest during exacerbation, Regarding Hemoglobin, TLC, Platelets there was no statistically significant differences between the studied groups (p= 0.085, 0.091 and  respectively), Regarding neutrophils, eosinophil and monocytes there were statistically significant differences between groups.