Background: Childhood cancer incidence has shown an increase over time. Despite all the improvements in treatment and diagnostic techniques in the field of oncology during the past decades, cancer remains the second main reason of death in children under 15 years old in most parts of the world. Aim of the study: To describe the pattern of childhood cancers in Minia governorate, Egypt. Methodology: A cross sectional study included 96 children with established diagnosis of cancer aged from two up to 18 years old. The data collected via interviewed questionnaire with mothers of children diagnosed with cancer who attended Minia oncology center during the period from January to November 2020. Results: The most frequent type of cancer in children was leukemia (27.1%), followed by lymphoma (26%). The least frequent tumors were retinoblastoma and unspecified malignant neoplasms (2.1% and 1%, respectively).  Leukemia and lymphoma were higher in males than females, while brain and spinal tumors, kidney tumors and retinoblastoma were higher in females than males.  Conclusion: Leukemia and lymphoma are the commonest childhood cancer with more predilections toward males.     ___________________________________________________________________________