This study aims to investigate the relationship between logistics investment and economic growth by determining the direct and indirect impact of investment in the entire logistics sector along with the classified one on economic growth. The panel data is used for two groups of countries: six Arab countries for the period 2007-2016 and 31 OECD countries for the period 2007-2018. This study adopts a path analysis approach based on the mediation analysis using the product of coefficients method combined with the bootstrapping method to test the direct and indirect effects of the relationship between total logistic investment and economic growth based on three mediators. This study contributes to the literature by filling the gap of determining the indirect impact of logistics investment on economic growth (whether for the entire logistics sector or classified for several areas) and it is unlike other studies that focused on the direct impact only. The present study proves that the relationship between logistical investment and economic growth, whether directly or indirectly, was not clear in the Arab countries, in contrast to the situation in the OECD countries, which has a direct and indirect effect between logistical investment and economic growth through logistics efficiency, competitiveness and trade openness as mediators in this relationship.