Nanotechnology became applicable in numerous fields. Its applications in the fields of architecture and interiors represent a rich field through producing new materials and improving other ones that are already exists through the formation and production of those materials in nanoscales which causes leaps in their features and characteristics. Researchers recently could improve and invent nanomaterials with super-quality applications in materials of construction, finishing and different interiors' elements that created safe interiors of their occupants. The research includes the terms of nanotechnology and its effects on architecture and interior design, and studying the shape and function abilities of nanomaterials and their different applications in interiors especially for museums. The research also study examples of international museums and the applications of nanotechnology in their interiors. Finally, the research includes a comparative study for two international museums one in Egypt and the other in Italy from nanotechnology perspective.