This research presents the findings of an experimental study probing the impact of façade opening design on energy consumption in offices in Egypt. This study aims to provide considerations and insights for architects and relevant professionals for designing office façades. This will be achieved through conducting a trial on a software design program with the aim of overcoming high energy costs and optimizing interior thermal comfort of occupants. The exploration builds upon former studies that stressed the significance of façade design in achieving optimal thermal comfort and energy effectiveness. Accordingly, the research adopts a comprehensive experimental approach that incorporates building simulation using a design program (Rhino and Design Builder) based on recommendations from former studies. The program encompasses factors such as window-to-wall ratios, shading systems, glazing options, office façade exposure, and interior partition types. The trial involves the development of computer-generated mock office model of parametric façade design and other façade design configurations. The temperature, moisture, and energy consumption are then measured and analysed for each design alternative. This exploration contributes to the advancement of sustainable design practices in Egypt by providing valuable information and insights for designing office façades. Architects, engineers, and relevant professionals can utilize these findings in the design process to optimize the energy efficiency of office spaces in Egypt, offering a more comfortable and productive space for users.