Background
 Menetrier's disease is an uncommon disease characterized by diffuse hypertrophy of gastric mucosa and giant gastric rugae with an increased risk of gastric cancer. Only a few reports supporting its association with gastric cancer have been found.
Material and methods
We present the case of signet ring cell adenocarcinoma associated with Menetrier's disease. The patient is a 54-year-old Algerian female.
Results
A 54-year-old woman was admitted to our hospital with a history of anemia, anorexia, and 10 kg weight loss. During her hospitalization, the patient presented an extradural hematoma. A biopsy was performed, which revealed a bone metastasis of the carcinomatous process. Abdominal computed tomography demonstrated diffuse thickening of the gastric wall. A gastric biopsy specimen showed thickened gastric mucosa and cystic dilatation of glands compatible with Menetrier's disease and diffuse infiltration by signet ring cell adenocarcinoma. A total gastrectomy was performed.
Conclusion
A patient with signet ring cell adenocarcinoma associated with Menetrier's disease is reported in our case study.