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327578

Early Detection and prediction of survival of patients with Hepatocellular Carcinoma Using Transient Elastography

Article

Last updated: 28 Dec 2024

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Abstract

Background:
Detection of early cases of HCC allows for offering curative interventions that may positively impact the survival of patients. Screening depends on the use of ultrasound with or without alpha-fetoprotein. However, some cases might need to be noticed, so alternatives are needed. Transient elastography can be studied as an effective alternative.
Methods:
Patients were divided into groups with liver cirrhosis and HCC and another group without HCC. Demographic criteria and laboratory profiles were compared. Transient elastography was then performed, and values of Controlled Attenuation Parameters (CAP) and liver stiffness were compared between both groups.
Results:
One hundred thirty-three patients with liver cirrhosis and HCC and 133 patients without HCC were studied. Our study showed that patients with HCC had significantly lower steatosis as measured by CAP using transient elastography (p-value < 0.001). However, they had substantially higher fibrosis (p-value < 0.001). A cutoff level of >24.3 Kpa showed a 90.5% sensitivity, 85.7% specificity, 86.4% PPV and 90% NPV for predicting the occurrence of HCC. By using univariate analysis, smoking was a significant predictor for mortality of HCC patients. In contrast, the multivariate analysis showed that gender was an independent predictor for mortality in patients with HCC. Liver stiffness measurement was not shown to predict survival in patients with HCC.
Conclusion:
Detection of early HCC is essential to gain the utmost benefit from the available therapeutic options. Transient elastography may provide a tool for diagnosing patients in the early stages. However, it might not be a good predictor of overall survival.

DOI

10.21608/ajgh.2023.245244.1039

Keywords

hepatitis C, HCC, Screening, Liver fibrosis, Transient elastography

Authors

First Name

Mohamed

Last Name

Hashem

MiddleName

B.

Affiliation

Endemic medicine department, Faculty of Medicine, Cairo University

Email

mohamed.bassam@kasralainy.edu.eg

City

-

Orcid

-

First Name

Hend

Last Name

Shousha

MiddleName

Ibrahim

Affiliation

Endemic Medicine Department, Faculty of Medicine, Cairo University

Email

hendshousha@yahoo.com

City

-

Orcid

-

First Name

Mohammed

Last Name

Abou Hia Allah

MiddleName

N.

Affiliation

Hepatogastroenterology and Infectious diseases department, Faculty of Medicine, Al-Azhar University

Email

mohammedabouhiaallah@hotmail.com

City

-

Orcid

-

First Name

Ashraf

Last Name

Abdelaziz

MiddleName

Omar

Affiliation

Endemic Medicine Department, Faculty of Medicine, Cairo University

Email

abdelazizashraf@hotmail.com

City

-

Orcid

-

First Name

Mohammed

Last Name

Al-Nadry

MiddleName

H.

Affiliation

Hepatogastroenterology and Infectious diseases department, Faculty of Medicine, Al-Azhar University

Email

mohammedalnadry@hotmail.com

City

-

Orcid

-

First Name

Walid

Last Name

Gomaa

MiddleName

M.

Affiliation

Hepatogastroenterology and Infectious diseases department, Faculty of Medicine, Al-Azhar University

Email

walidgomaa@hotmail.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Abdel-Halim

MiddleName

M.

Affiliation

Hepatogastroenterology and Infectious diseases department, Faculty of Medicine, Al-Azhar University

Email

mohammedabdelhalim@hotmail.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Nabeel

MiddleName

Mahmoud

Affiliation

Endemic Medicine Department, Faculty of Medicine, Cairo University

Email

mmahmoud72eg@gmail.com

City

-

Orcid

-

First Name

Tamer

Last Name

Elbaz

MiddleName

Mahmoud

Affiliation

Endemic Medicine Department, Faculty of Medicine, Cairo University

Email

tamerbaz@yahoo.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Abdelmaksoud

MiddleName

Hosni

Affiliation

Diagnostic and interventional radiology department, Faculty of Medicine, Cairo University

Email

aahmedhosni@hotmail.com

City

-

Orcid

-

First Name

Hedy

Last Name

Badary

MiddleName

A.

Affiliation

Endemic Medicine Department, Faculty of Medicine, Cairo University

Email

hedy.ayman@gmail.com

City

-

Orcid

-

Volume

7

Article Issue

1

Related Issue

45457

Issue Date

2024-01-01

Receive Date

2023-10-28

Publish Date

2024-01-01

Page Start

1

Page End

23

Print ISSN

2735-5489

Online ISSN

2735-5497

Article File

AJGH_Volume 7_Issue 1_Pages 1-23.pdf

PDF . 567.6kB

Link

https://ajgh.journals.ekb.eg/article_327578.html

Detail API

https://ajgh.journals.ekb.eg/service?article_code=327578

Order

1

Type

Original Clinical

Type Code

2,189

Publication Type

Journal

Publication Title

African Journal of Gastroenterology and Hepatology

Publication Link

https://ajgh.journals.ekb.eg/

MainTitle

Early Detection and prediction of survival of patients with Hepatocellular Carcinoma Using Transient Elastography

Details

Type

Article

Created At

28 Dec 2024