Weed and disease management strategies for sustainable sugarcane production were investigated by using two sugarcane genotypes, Bida local and commercial NCS 001, four rates of sugarcane trash mulch rates of 0, 3, 6, 9 t ha^-1 and four weed management practices namely weedy check, monthly hoe weeding for five months (5 MHW), application of PE diuron + POE 3 – maize force, and application of PE diuron plus POE 3 – maize force + 2 MHW at Badeggi (Lat. 9^o 45^́՜ N, Long. 06^o 07^՜ E). The treatments were arranged in a split-plot design and replicated three times in 2016 and 2017 cropping seasons. Results showed that application of 6 t ha^-1 mulch produced comparable but lower weed dry matter and whip smut incidence to 9 t ha^-1 mulch. Application of PE diuron plus POE 3 – maize force and 5 MHW, resulted in a comparable weed dry matter and whip smut incidence to PE diuron plus POE 3 – maize force plus 2 MHW. Similarly, PE diuron plus POE 3 – maize force, 5 MHW and PE diuron plus POE 3 – maize force plus 2 MHW produced comparable stalks and brix content, number of stools and millable stalks. Also, 5 MHW generated taller sugarcane plants. The application of PE diuron plus POE 3 – maize force proved equally effective as 5 MHW in contributing the highest cane yield. Lower weed dry matter was recorded in Bida local, and taller stalks, maximum cane girth, higher brix content, number of stools, millable stalks, lower whip smut incidence and cane yield were recorded in NCS 001. In all, application of 9 t ha^-1 trash mulch with 5 MHW or PE diuron plus POE 3 – maize force plus 2 MHW or PE diuron plus POE 3 – maize force strategies effectively managed weeds and smut incidence in the present study. The strategies also increased stalk height, cane girth, brix content, number of stools, millable stalks and cane yield of genotype NCS 001.