This study investigated the effects of adding 150, 300, and 450 mg/kg of chelated organic zinc amino acids (CH-ZnAA) to rabbits' diets on some physiological and productive performance. Forty weaned V-line rabbits were assigned to four equal groups, nominated as T1 (Control, fed basal diet without any supplementation), T2 (fed basal diet plus 150 mg/kg diet), T3 (fed basal diet plus 300 mg/kg diet), and T4 (fed basal diet plus 450 mg/kg diet), respectively. The results showed that diets supplemented with 150, 300, and 450 mg CH-ZnAA/kg diet increased the average body weight (ABW) and average weight gain (AWG) as well as, final body weight (FBW) and total body weight gain (TBWG) of experimental animals as compared to control group. In the same line, an improvement was recorded in digestibility of crude protein (CP), ether extract (EE), crude fiber (CF), and nitrogen-free extract (NFE) with CH-ZnAA. Moreover, it was found that the rising inclusion of CH-ZnAA from 150 up to 450 mg/kg in the rabbits' diets improved slaughter weight (SW), hot carcass weight (HCW), and HCW + total edible (HCWE). Total erythrocyte counts (RBCs), hemoglobin (Hb, g/dl), and Hematocrit (Hct%) were increased when different levels of CH-ZnAA were supplemented to rabbit diets; however, supplementation did not effect on the WBCs, platelets, or erythrocytic indices. These supplementations also improved total protein (TP), albumin (ALB), globulin (Glob), and glucose concentrations. No significant differences were noticed in liver enzymes [aspartate aminotransferase (AST) and alanine aminotransferase (ALT)], kidney functions (creatinine and urea) concentrations, and Thyroid hormones (triiodothyronine and thyroxin) among the studied treatments. Supplemented CH-ZnAA to the rabbits' diet up to 450 mg/kg improved serum levels of the antioxidants superoxide dismutase (SOD), glutathione S-transferase (GST), and decreased malondialdehyde (MDA) concentrations. The net revenue (NR) was improved by 11.11, 21.95, and 30.82 %, respectively when feeding diets T2, T3, and T4 vs T1 (control). In conclusion, CH-ZnAA improved the productivity of V-line rabbits, it is secure and might be advised for use.