Root knot nematodes (RKNs) are considered destructive plant parasitic nematodes of many host plants all over the world. Nematicidal potential of eight wild weeds i.e., Atriplex lindleyi, Chenopodium album, Hyoscyamus muticus, Mesembryanthemum nodiflorum, Pluchea dioscoridis, Senecio squalidus, Zygopyllum qatarense, and Amaranthus ascendens were tested against Meloidogyne spp. in vitro and in vivo on tomato plants. Results of in vitro tests indicated that A. lindleyi and C. album, recorded the highest percentage of egg hatching inhibition and larvae mortality by 97 and 100 % respectively at all exposure periods. Also, A. lindleyi at 4% of soil weight, recorded the highest reduction in nematode parameters i.e., number of galls, egg masses, females/root system and juveniles (J₂s)/250g soil, with 75, 80, 70 and 86%, respectively, Furthermore, tomato plant growth parameters i.e., root and shoot lengths, fresh root and shoot weights as well as plant dry weight were improved in treated plants compared with non-treated control. So that, weeds used in this study may be included in the plant parasitic nematode management programs.