Abstract Background:  The impact of food allergy on health-related quality of life (HRQL) amongst adolescents is incompletely understood. The aims of this study were to make use of the specific food allergy quality of life questionnaire-teenager form and to investigate the association between objectively-diagnosed staple food allergy and HRQL amongst adolescents. Methods:  In this cross-sectional study, 144 adolescents aged 12–18 years [n = 99 (69 %) boys] with objectively-diagnosed food allergy living in Ismailia, Egypt were included. Adolescents completed the specific food allergy quality of life questionnaire-teenager form, which has a corresponding scale of 1 = best HRQL, and 7 = worst HRQL. Over‑all HRQL and domain-specific HRQL were established. Adolescents also reported symptoms, prescription and presence of other food allergies. Inability to stand/collapse, and/or loss of consciousness. Clinically different HRQL was set at a mean difference of ≥0.1. Results:  Shows that, the average score of the food allergies scale are (167.93), which is in the high range by (93.99 %). The average quality of life measure for adolescents is 105.42 degrees (37.04%), which is considered a low level. There is a negative correlation between the statistically significant food allergies in adolescents and the quality of life dimensions at the level of significance 0.01, which highlights the importance of the current study.    Conclusions:  The study found that food allergies significantly affected the quality of life in adolescents. As well as low-income and educational level of the parents enhanced this effect to occur