One of the main side effects of diabetes mellitus caused by streptozotocin (STZ) is dyslipidemia. The objective of the current study is to assess the possible protection against dyslipidemia experimentally generated STZ-diabetes in rats provided by orange leaves extract (OLE). Orange is one of the most popular world fruit crops, with a high commercial value, and is grown primarily for fresh consumption as well as the production of fruit juice. Furthermore, its by-products contain essential bioactive chemicals with use in animal feed, manufactured meals, and health care. Indeed, orange fruits contain a high concentration of secondary metabolites, phytochemicals that play an important defensive and appealing role in plant-environment interactions. Due to their phenolic profile, orange extracts have been shown to have a wide range of promising biological effects, including antiatherogenic, anti-inflammatory, anticancer, anticlotting, and antioxidant actions. 25 adults male Wistar albino rats were divided into five groups: the diabetic untreated group, the diabetic control group, non-diabetic group treated with OLE (100 mg/kg/day), diabetic groups treated with OLE (100 mg/kg/day), and the diabetic group treated with metformin. The following parameters were assessed: FBS, TC, TG, HDL-c, LDL-c and VLDL-c. OLE significantly decreased FBS, TC, TG, LDL-c and VLDL-c in STZ-treated rats while increasing reduced HDL-c.