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303799

Novel Anti-microbials from Streptomyces albidoflavus SAC61 against Multidrug-Resistant Bacteria: Metabolomics and Molecular Modeling

Article

Last updated: 28 Dec 2024

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Subjects

-

Tags

Microbiology and Immunology

Abstract

Antibiotic resistance developing bacteria have led to a renewed interest in bioactive compounds, particularly antibiotics. The combination of Actinomycetes and their bioactive metabolites with scientists using advanced techniques such as genomics and metabolomics to identify new compounds with potential as antibiotics is a promising combination. This study tested metabolic organic extracts from 29 actinomycete strains against four human pathogenic bacterial reference cultures. The results highlighted the bioactivity of Streptomyces albidoflavus SAC61, with the lowest MIC as a potential source of novel antimicrobial agents against Pseudomonas aeruginosa and Escherichia coli. Non-targeted metabolomics and molecular modeling technique (LC-QTOF-MS-MS) were used to identify potential mechanisms of action and target sites of the produced antibiotic. This study highlights the potential of Streptomyces albidoflavus SAC61 strain extracts as a good source of potent antimicrobial products. It emphasizes the need for further research to isolate and identify more active compounds and recognizes their mechanisms of action to combat antibiotic resistance.

DOI

10.21608/aels.2023.215761.1035

Keywords

Actinomycetes, bioactive compounds, Antibiotic resistance, Streptomyces albidoflavus

Authors

First Name

Hanan

Last Name

Megawer

MiddleName

Khaled

Affiliation

Botany and Microbiology Department, Faculty of Science, Derna University, Algoba, Libya, Botany and Microbiology Department, Faculty of Science, Suez Canal University, Ismailia, Egypt

Email

hananaltalhy0@gmail.com

City

-

Orcid

0009-0006-6708-8424

First Name

Rabab

Last Name

Makharitta

MiddleName

-

Affiliation

Botany and Microbiology Department, Faculty of Science, Suez Canal University, Ismailia, Egypt, Department of Biology, College of Sciences and Arts, University of Jeddah, 21959, Khulis, Jeddah, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

Nafie

MiddleName

S.

Affiliation

Chemistry Department, Faculty of Science, Suez Canal University, Ismailia, 41522, Egypt

Email

mshaban402@gmail.com

City

-

Orcid

-

First Name

Raúl

Last Name

Riesco

MiddleName

-

Affiliation

Dpto. Microbiologíay Genética Lab. 214, University of Salamanca, 37007, Salamanca, Spain

Email

-

City

-

Orcid

-

First Name

Martha

Last Name

Trujillo

MiddleName

E

Affiliation

Dpto. Microbiologíay Genética Lab. 214, University of Salamanca, 37007, Salamanca, Spain

Email

-

City

-

Orcid

-

First Name

Amro

Last Name

Hanora

MiddleName

-

Affiliation

Microbiology Department, Faculty of Pharmacy, Suez Canal University, 41522, Ismailia, Egypt

Email

-

City

-

Orcid

-

First Name

Sahar

Last Name

El-Shatoury

MiddleName

A

Affiliation

Botany and Microbiology Department, Faculty of Science, Suez Canal University, Ismailia, Egypt

Email

sahar_hassan@science.suez.edu.eg

City

-

Orcid

https://orcid.org/00

Volume

4

Article Issue

2

Related Issue

43670

Issue Date

2023-07-01

Receive Date

2023-06-05

Publish Date

2023-07-01

Page Start

29

Page End

38

Print ISSN

2805-3060

Online ISSN

2805-3079

Article File

AELS_Volume 4_Issue 2_Pages 29-38.pdf

PDF . 1.4MB

Link

https://aels.journals.ekb.eg/article_303799.html

Detail API

https://aels.journals.ekb.eg/service?article_code=303799

Order

4

Type

Original research articles

Type Code

2,116

Publication Type

Journal

Publication Title

Advances in Environmental and Life Sciences

Publication Link

https://aels.journals.ekb.eg/

MainTitle

Novel Anti-microbials from Streptomyces albidoflavus SAC61 against Multidrug-Resistant Bacteria: Metabolomics and Molecular Modeling

Details

Type

Article

Created At

28 Dec 2024