Background: Clinical governance (CG) is a set of practices to reduce risks for patients and hospital staff. These practices include early detection of serious complications, investigation of patient complaints, application of the best available evidence when making clinical decisions, self-evaluation of performance, use of practical techniques to alter service providers' behavior, and ongoing evaluation of programs for service providers' job advancement. Aim: the study aimed to determine the Barriers to Implementing Clinical Governance from the Perspective of Health Care Providers. Settings: The study was conducted in two hospitals affiliated with MOHP: El-Gomhoria Hospital and Gamal Hamada. Subjects: All healthcare providers (N= 389) available at the time of data collection in the previous study settings with exclusion criteria of less than six months. Tool: Barriers of Clinical Governance Questionnaire to assess barriers to implementing clinical governance in the study settings. Results: The highest barriers to implementation of clinical governance as perceived by healthcare providers were related to infrastructure 85.64%, followed by human resources 73.95%. Also, there was a significant difference between previous attendance of workshops regarding clinical governance and healthcare providers' perception of the barriers to CG implementation (p =0.004); Conclusion: Interventions related to management, human resources, organizational culture, and education are crucial to successfully implementing clinical governance. Addressing these areas in the clinical governance plan is crucial for finding significant solutions Recommendations: Develop comprehensive training programs on the principles and practices of clinical governance and provide ongoing professional development opportunities for healthcare providers to enhance their understanding and implementation of clinical governance.