Background: As healthcare continues to evolve and face complex challenges, the cultivation of innovative cultures and innovative work behaviors among nurses becomes increasingly essential for promoting the sustainability and growth of the nursing profession and healthcare organizations. Aim: This study aims to assess the prevalence of innovative work behavior among critical care nurses. Method: This is a descriptive study that was conducted at all critical units of Alexandria Main University Hospital, Egypt. Data were collected from 360 nurses who were conveniently selected using the Innovative Behavior Inventory Questionnaire (IBIQ). Results: The overall mean score of nurses' innovative work behavior was 66.03 ± 8.35. Also, 96.1% of nurses had a moderate perceived level of innovative work behavior. Idea generation had the highest average score (2.96 ± 0.54) among the dimensions of innovative work behavior whereas implementing starting activities had the lowest average score (2.76 ± 0.52). Conclusion: It is concluded that the road toward innovation in nursing practice seems to be paved since nurses have a moderate level of innovative work behavior, giving a promising future to the nursing profession. Recommendations: Nurse managers should provide continuous training programs to enhance innovative behavior among critical care nurses. Also, identifying innovative nurses and encouraging them to maintain and enhance innovative attitudes is a cornerstone task for the cultivation of innovation.