Background: A flipped classroom (FC) is a new pedagogical method in which the lecture and homework activities of a course are reversed. Students are required to review pre-recorded lectures before each class, and in-class hours are used for various learning activities, including open discussion, collaborative group activities, critical thinking activities, and hands-on activities. FC facilitates interaction between students and educators and between students themselves. This model encourages students to take the initiative in learning and allows them to study at their own pace. Objective: This study aimed to assess FC strategy application as perceived by nursing students. Settings: The study was carried out at the Faculty of Nursing, Damanhour University, during the first semester of the academic year 2022-2023. Subjects: A convenient sample of 450 third-year nursing students enrolled in the Critical Care (1) course during the academic year 2022-2023. Tools: two tools were used. “Nursing students' perception toward the application of FC" and “Challenges toward the application of flipped classroom". Results: The results of this study showed that there were statistically significant differences between overall nursing students' perceptions before and after the application of the FC strategy. Conclusion: FC is a promising alternative to traditional lectures in nursing education that solves the problem of an increased number of nursing students and a shortage of staff. Besides, it helps students become more engaged in the classroom. Recommendations: Implementation of the FC strategy in other courses and for students in different class levels will facilitate the learning process. Conduct more training workshops about FC for all nursing students and educators, especially the newly appointed.