Background: Discontinuation of contraception is an issue of public health significance, since it often leads to unintended pregnancies that are costly to the individual and public as a whole. Objective: explore the factors associated with discontinuation of using hormonal contraceptives. Settings: The study was carried out at 20 Family Planning Clinics; 4 outpatient clinics affiliated to 4 hospitals, The remaining 16 Family Planning outpatient clinics affiliated to Family Health centers. Tools: Three main tools were used in this study, The first tool was Socio-demographic and reproductive history. The second tool Women's knowledge about hormonal contraceptive methods. The third tool was Factors associated with discontinuation of hormonal contraceptive methods. Results: findings of the present study revealed that the most (94.5%) of the studied subjects had poor knowledge about the hormonal contraceptive methods, and the majority ( 86% )of the studied women discontinued hormonal contraceptive methods due to health factors. conclusion: the current study showed that there is statistical significance between women's knowledge and the factors affected discontinuation of using hormonal contraceptive methods. Recommendations: Strengthening health education and improving counseling, conclusion practice for women and couples seeking FP services, especially on hormonal contraceptive methods .