Background: Orthopedic nurses are at higher risk for low back damage while providing patient care, so correct body mechanics are essential for a healthy occupation. Aim: This study aimed to identify the relationship between utilization of body mechanics and low back pain among nurses working in the orthopedic departments. Design: A descriptive correlational research design was utilized. Setting: The study was carried out in three hospitals Benha University, Toukh Central Hospital, Benha Teaching Hospital It included all nurses in orthopedic department. Subjects: A convenience sample of seventy nurses (70) was recruited from the mentioned settings. (20) nurses from Benha University Hospital, (40) nurses from Toukh Central Hospital, and (10) nurses from Benha Teaching Hospital. Tools: Tool I: Nurses' Socio demographic and Clinical Data Structured Questionnaire, Tool II: Nurses' Utilization of Body Mechanics: Observational Checklist, Tool III: Low Back Pain Assessment. Results: The majority of the studied nurses (75.7 %) had LBP, 100% of them had unsatisfactory utilization of body mechanics. Conclusion: No statistical correlation between body mechanics and low back pain. Also, the majority of the studied nurses didn't receive any training, and didn't practice proper body mechanics. Recommendations: Replication of the study on large probability sampling.