Background: Mothers who have children with Cerebral Palsy (CP) experience numerous difficulties that affect their physical and psychological health, social relationships, and financial situation. These countless challenges have negative impact on mothers' Quality of Life (QOL) and the entire family dynamics. The study aimed to identify quality of life of mothers having children with cerebral palsy. Settings: The study was conducted in the Outpatient Psychiatric and Neurological Clinic at the Specialized University Hospital for children at Smouha, and the Rehabilitation and Physiotherapy Department at EL-Raml Hospital for Children (Wingat) in Alexandria. Subjects: A convenient sample of 100 mothers who have children with any type of CP comprised the study subjects. Tools: Two tools named Pediatric Quality of Life Inventory: Family Impact Module and Gross Motor Function Classification System were used for data collection. Results: Fifty-seven percent of mothers who have children with CP had "low" QOL level, while 30% of them had "moderate" level and only 13% had "high" level. The overall parent functioning and family functioning were "low" among 66% and 37% of mothers respectively. Conclusion: It was concluded from this study that QOL was low among more than half of mothers who have children with CP, while nearly one-third of them had moderate level.