Background: Profound functional impairments and poor quality of life have been associated with the negative symptoms of schizophrenia. Psychosocial therapies aimed at bettering the management of these symptoms alone frequently fail to enhance patients' functioning and quality of life. So, clarifying the relationship between these variables represents an important step in understanding the concept of QoL and IADL, to guide developing future treatment efforts that could assist the psychiatric nurse in developing a plan of care for rehabilitating patients with schizophrenia. Aim: To assess the levels of the negative symptoms, IADL and QoL among patients with schizophrenia and to determine the relationship between negative symptoms and each of IADL, and QoL among those patients. Setting: El-Maamoura Hospital for Psychiatric Medicine's outpatient clinic in Alexandria, Egypt. Subjects: A convenient sample size of 200 people who had been diagnosed with schizophrenia. Tools: A Socio-Demographic and Clinical Data Structured Interview Schedule, Scale for the Assessment of Negative Symptoms of Schizophrenia (SANS), World Health Organization Quality of Life Scale–Brief Version (WHOQoL–BREF), and Instrumental Activities of Daily Living (IADL) Scale. Results: Participants' total score of Negative Symptoms of Schizophrenia Scale (SANS) was highly significantly negatively correlated with each of overall scores of Instrumental Activities of Daily Living and Quality of Life (P<0.001). Conclusion: Increased level of negative symptoms causes decreased level of performance on instrumental activities of daily living and quality of life. In addition, both the quality of life and the capacity to do the instrumental activities of everyday life suffer when negative symptoms are present in a great level. Recommendations: Routine clinical assessments and the development of individualized rehabilitation programs for people with schizophrenia must include careful consideration of the evaluation of negative symptoms, instrumental activities of daily living, and quality of life. Further studies to examine factors that affect Instrumental Activities of Daily Living and Quality of Life among patients with schizophrenia are needed.