Background: Resilience in nurses enables them to use positive adaptive skills in coping with stress and helps them keep up with the stressful environment of their work settings and it was proven that resilience was the most significant positive factor contributing to work engagement. It is difficult to accomplish high-quality patient care without nurse work engagement (WE), and in the current complex healthcare environment, the engagement of the nursing workforce is essential for delivering quality patient care and overcoming current challenges in healthcare. Objective: Determine the effect of resilience training program for nurse interns on their work engagement at their work settings. Setting: The study was conducted at internship hospitals of Faculty of Nursing, Damanhour University, where all nurse interns for the academic year 2021/2022 were attending their internship year. Subjects: The study subject included a simple random sample of nurse interns (n = 80).The subjects were divided into two groups, study group (n= 40) and control group (n= 40). Tools: Four tools were used in this study: Connor-Davidson Resilience Scale; Utrecht Work Engagement Scale (UWES); Resilience Knowledge Assessment Questionnaire, and Training Program Evaluation Questionnaire (TPEQ). Results: The study showed that there was a highly statistically significant correlation between nurse interns' resilience and their work engagement. Furthermore, nurse interns' resilience in the study group has significant differences at three phases of program assessment, immediately post phase and at follow up. Conclusion: The implementation of resilience training program for nurse interns significantly improved the resilience level of nurse interns which in turn improved the level of nurse interns' work engagement. Recommendations: Nurse interns should be monitored for their levels of resilience and burnout by internship department in faculty of nursing and take the appropriate action in case of low levels of energy to improve their motivation and resilience. Also, nurse interns should attend a resilience training program at the beginning of the internship year.