Background: End-stage renal disease (ESRD) is a serious irreversible progressive disease with 
high prevalence worldwide, that makes life un sustainable in the absence of renal replacement 
therapy, hemodialysis (HD) is the most widely used therapy. Objective: To determine the effect of 
intradialytic exercise on physiological parameters, biochemical markers, and quality of life among 
patients on hemodialysis. Design: a quasi-experimental research design. Setting: The study was 
conducted at the hemodialysis units of the National Medical Institute in Damanhur, Elbeheira 
governorate. Subjects: A convenience sample of 50 patients. Tools: two tools were used for data 
collection. The first tool was Socio- demographic and Clinical Data Structured Interview Schedule.
The second tool was the Kidney Diseases Quality of Life Short Form (KDQoL-SFTM 1.3). Results: 
Intradialytic exercise program has a positive effect in reduction of serum urea and creatinine and 
improving levels of some electrolytes as serum phosphate, potassium, calcium, haemoglobin level, 
Systolic and diastolic blood pressure. In addition, there was a significant statistical difference
between the study and control groups in most domains of QOL (P < 0.05) except work status and staff 
encouragement. Conclusion: The study concluded that hemodialysis patients who practice 
intradialytic exercise exhibit significant improvement in biochemical markers, blood pressure and 
quality of life than those who don`t practices it. Recommendations: Application of educational 
program should be carried out for hemodialysis patients at hemodialysis unit to be aware about the 
importance of intradialytic exercises which help them to improve their quality of life.