The pomegranate (Punica granatum L.), a plant of the Punicaceae family, is one of the first known edible fruits. To determine the impact of four levels of zinc sulphate (500, 1000, 1500, and 2000 ppm) on vegetative growth and fruit quality, this study was conducted during the 2021 and 2022 growing seasons on Manfalouty and Hejazy pomegranate cultivars in the Pomology Orchard at the Faculty of Agriculture, Assiut University. Three replicates of a factorial experiment were done following the (RCBD). The findings showed that the application of Zinc Sulfate at 2000 ppm had led to a significant effect on leaf area (cm2) and almost physical and chemical properties (excluding acidity, TSS/acid that were most affected by 500 ppm). Hence, it could be concluded that application of ZnSo4 (2000 ppm) at full bloom and a month after full bloom was the best treatment to improve vegetative, physical properties and fruit quality of Manfalouty and Hejazy Pomegranate cultivars under Assiut climatic conditions.