Background: Evidence-based practice has been considered as a key for healthcare quality measure. As a result of its influence on nurses' knowledge and practice, evidence-based practice has gained prominence in the nursing profession. Therefore, evidence-based practice is increasingly acknowledged as a critical component of improving the quality of healthcare and nursing care services, as well as achieving patient care excellence. The study aimed to explore nurses' knowledge and attitudes toward implementing evidence-based practice. Research design: A cross-sectional research design was used to answer the study question. Sample: A convenient sampling of 100 nurses from staff nurses. Setting: The study was applied at Minia University Hospitals. Tools of data collection: Two tools were used, 1^st tool was personal and professional data the second part was nurses' knowledge related to implementation of evidence-based nursing practice, and 2^nd tool: was the evidence-based practice attitude scale. Results:  The study revealed that (34.5%) of nurses had satisfactory knowledge, while (37.9%) of nurses had a negative attitude toward evidence-based nursing practice implementation.Conclusion: There a positive correlation between nurses' knowledge and attitude toward evidence-based nursing practice implementation. This study provides a foundation for the adoption of measures to encourage the use of EBP by nurses in different healthcare settings in Egypt, as well as a baseline assessment for upcoming reviews.
Recommendations: Carefully crafted evidence-based programs, properly equipped facilities with state-of-the-art informatics tools.