Background: Pyrexia is a natural response of the body that helps in fighting off foreign substances such as microorganisms and toxins. Warm water compresses lead to blood vessels to dilate and improves blood circulation, which releases heat in the form of sweat and supplies oxygen to brain cells, which stimulates circulation and reduces body temperature. Aim of the Study: to explore the effect of applying cold gel compresses versus warm water compresses on reducing body temperature among children with pyrexia. Subject and method: a quasi-experimental research design used to achieve the aim of the current study. Setting: The current study was conducted in the pediatric department on the third and fourth floors at Minia University Hospital for Gynecology, Obstetrics, and Pediatrics. A purposeful sample of 70 children under five years with pyrexia were participated in the study. Data collected Tool through the use of one tool: It covered the following parts: Part (1): Bio-demographic data of the children and Part (2): Vital signs record included axillary body temperature, heart rate, and respiratory rate. Result: The mean axillary body temperature before compresses in cold gel and warm water groups was 38.8 ± 0.5^oC versus 38.9 ± 0.5^oC respectively, and after 60, 120 minutes decreased in cold gel compresses group was 38.6⁰C ± 0.6 and 38.3⁰C ± 0.6, while in warm water compresses group was 38.2 ⁰C ± 0.5 and 37.4⁰C ± 0.5 respectively with statistical significances. Conclusion: As pointed the current research results showed that warm water compresses are more effective than cold gel compresses in reducing body temperature among children with pyrexia. Recommendation: Develop health education program for nurses regarding different methods of non-pharmacological techniques to reduce body temperature.