Background: Quality of care is one of the most frequently quoted principles of health policy, and it is currently high up on the agenda of policy-makers at national and international levels. Patient safety is often considered a component of quality thus; practices improving patient safety lead to improvement the overall quality of care. Aim: to investigate the effectiveness of educational program about implementing PDCA process of quality on head nurses practice regarding patient safety goals. Research design: Quasi-experimental research design was utilized in this study. Setting: The study was conducted at Minia Liver University Hospital, Minia Urology and Renal University Hospital and Minia Emergency University Hospital.Subjects: All head nurses available which constitute (50), who worked at Minia university hospitals during the time of data collection. Tools: two tools as follow; tool (I), first part was socio demographic data, and second part was head nurses' knowledge about PDCA process of quality and patient safety goals questionnaire. Tool (II) was head nurse practice of PDCA process related to patient safety goals questionnaire. Results: the highest percentage of head nurses had low level of knowledge about PDCA process of quality and patient safety goals pre implementation of the program with (66.0%) and (74.0%) respectively, while the highest percentage of them had high level of knowledge about PDCA process of quality and patient safety goals immediately after implementation of the program with (90%) & (92%) respectively. Also, The highest percentage of head nurses had low level of practice of PDCA process related to patient safety goals pre implementation of the program with (84.0%), while (86.0%) of them have high level of practice immediately after implementation of the program, Conclusion: there was moderate association between total head nurses knowledge and their practice regarding PDCA process of quality and patient safety goals post implementation of the educational program. Recommendation: Continuous training programs and development activities about the international patient safety goals and quality improvement models should be applied to all head nurses in the study setting and should be extended to other similar settings.