Background: Asthma is one of the most prevalent chronic diseases around the world and has a significant impact on quality of life of patients due to their duration, disabilities and exacerbations. Aim: To evaluate the effect of self- care management program for asthma patients on their quality of life. Design: A quasi-experimental research design was utilized. Setting: The current study was carried out at Minia University Cardiothorathic Hospital in inpatient Chest Department and followed up in the Chest Outpatient Clinic. Subjects: A purposive sample of 66 adult asthmatic patients (males and females).Tools: Two tools were used: First Tool: Patient Health Assessment, includes two parts, First Part: Socio-demographic data Second Part: Medical data. Second Tool: Asthma Quality of Life Questionnaire. Results: About (27.7 %) of the subjects had severe impairment of their asthma quality of life on pre test, while (18.5 %) of the subjects had minimum impairment of their asthma quality of life after one month from the application of self care management program (SCMP) and about (90.8 %) of subjects had moderate impairment of their asthma quality of life on follow up after 3 months. Conclusion: implementation of (SCMP) affected positively and helped in improving quality of life of asthmatic patients compared to pre (SCMP). Recommendations: Continues (SCMP) for asthmatic patients on a larger probability sample from dissimilar geographical settings to generalize the finding.