Background: Placenta previa is a serious pregnancy complication associated with increased risk of bleeding and other complications for both mother and fetus. Aim: This study aimed to assess the effect of Self-care guidelines for pregnant women with placenta previa on their maternal and fetal outcomes Design: Quasi- experimental research design was used. Setting: Conducted at Maternity and Child Minia University Hospital in Egypt. Sample: A purposive sample of 80 patients, were equally divided into study and control groups (1:1), between the first of March and the end of October 2023. Tool: Three tools were used: A structured interview questionnaire (Socio Demographic and Obstetric characteristics), assessment of general women and fetal health condition & signs and symptoms of placenta previa, and assessment of maternal and fetal Outcomes. Results: In this study placenta previa is most common in the age group between 25-30 years (47.5%, 40%), multiparity (86.8%, 83.8%), and previous CS (94.7%, 94. 6%) in study and control group respectively. In additionally 92.5% of the women in study group have a satisfactory care practices regarding total self- care guidelines, compared to only 15% in control group with highly statistically significant differences at p-value <0.01. Conclusion: This study concludes that implementing self-care guidelines practices lead to better outcomes for both mothers and fetuses in cases of placenta previa in study group than control group. Recommendations: It is recommended that these guidelines be incorporated as a standard protocol in maternity hospitals to support women with high-risk pregnancies and enhance overall outcomes.