Background: Ensuring patient safety during intrahospital transportation (IHT) is a worldwide critical concern in healthcare settings. Critically ill patients are particularly vulnerable to complications during IHT. Aim: This study aimed to identify the risk factors affecting the intrahospital transport of critically ill patients at oncology center. Methods: A descriptive, observational design was utilized to collect data from two intensive care units (ICUs) at Mansoura oncology center in Egypt. The study included sixty adult patients undergoing IHT from the ICU to other departments. Two tools were used to gather information. Tool I: patient's demographic and medical relevant data, tool II:  patients' risk factors during intrahospital transport that includes equipment-related factors, patient-related factors, transportation process factors, and staff-related factors. Results: The study revealed that 66.7% of patients were aged 50 years or older, The average score for equipment/material was 1.88 ± 0.324, and the total mean score for equipment-related risk factors was 4.1 ± 1.203. Patient-related risk factors included being away from the ICU for one hour (93.3%), severity of illness (70%), absence of agitation (98.3%), and urinary catheter as an invasive device (96.7%). Transportation-related factors such as daytime transportation (70%), elective urgency of transportation, receiving at the radiology department (96.7%), trolley transportation mode (96.7%), and transportation within 30 minutes (93.3%) were also identified as significant risks. Furthermore, staff-related risk factors included the absence of physicians (71.7%), physicians who had not received previous transport training courses (100%), and diploma-qualified nursing staff (100%). Conclusion: Equipment-related factors represent significant factors during IHT of critically ill patients. Recommendations: This study highlights the importance of developing protocols and guidelines to enhance safety during IHT and to improve patient outcomes.