Background: Nursing care of intubated patients is a high risk, complex intervention that can lead to several complications. Misconduct of practice and negligence to meet the required standards of care may cause patient harm, elevate treatment costs, and increase patients' ICU stay. Aim: Evaluate the effect of educational program on critical care nurses' performance of cuffed endotracheal tube care. Sampling: All critical care nurses on duty regardless of their personal data, their total number were 60 nurses. Tools of Data Collection: The First Tool: Socio demographic characteristics of ICU nurses that include (age, gender, qualification, work place, and years of experience and attendance of training courses) Second Tool: Nurse Knowledge assessment questionnaire: Used to assess the nurses' knowledge level about the cuffed ETT care. Third Tool: Nurses' practice checklist for cuffed endotracheal tube care used by investigator to assess ICUs nurses' practice level while applying the cuffed EET care. Results: Reveals that 6.7% of study participants represents a satisfactory knowledge level pre application of the blended learning educational program which improved to 96.7% post 2 weeks followed by slightly decrease 95% Post 3 months. Conclusion: The current study concluded that implementing an educational program regarding cuffed endotracheal tube care using the blended method significantly improve the nurses' performance regarding cuffed endotracheal tube care. Recommendations: Blended training should be widely used for all nurses in different units and departments to ensure updated knowledge and practices through continuing education center