Background: The success of dialysis depends on the patient's adherence to the prescribed treatment regimen, fluids, and dietary plans, and non-compliance will lead to deterioration in the patient's condition. The aim of the study is to evaluate the therapeutic nutrition adherence level among hemodialysis patients after receiving nursing instructions. Research design: A quasi-experimental research design will be utilized to fulfill the aim of this study. Setting: This study will be carried out at the hemodialysis unit at the Nephrology and Urology Hospital at Minia University, Minia City, Egypt. Subjects: A purposive sample is composed of 87 patients according to the sample size formula, and those willing to participate in the study will be included. Tools of Data Collection: Three tools were designed and used for collecting data for this study. The first tool was an interview questionnaire sheet, which includes two parts. 1st Part: Socio demographics, and 2nd Part: Medical Data of the Patient, Second Tool: Therapeutic Nutrition Adherence Questionnaire, which includes three parts. 1st Part: Diet Adherence Questionnaire, 2nd Part: Fluid Adherence, 3rd Part: Weight Measurements and Third Tool: Pitting Edema Scale Educational Protocol about Nursing Instruction for Hemodialysis Patients' Results: There was a highly statistically significant improvement in the patient's response to diet and fluid restrictions compared to pre- and post-intervention. Recommendation: Greater attention and close observation from the hospital on patient adherence to therapeutic nutrition and replication of the study should be done on a large sample.