Background Vitiligo is one of the most common skin diseases in the world. According to the World Health Organization (WHO), the number of people suffering from vitiligo is growing year by year and vitiligo becomes worldwide problem. Aim: to assess the awareness and psychological status of vitiligo patients in selected dermatological hospitals at Minia city. Research design:descriptive cross-sectional design was used to conduct this stud. Sample: convenient sample 130 patients suffering from vitiligo disease was used in this study through three months. Setting: The study was conducted at two places at Western Dermatology and leprosy clinic and Dermatology outpatient clinics at Minia University hospital that works at all days except Friday. Data collection: Data was collected through: four tools. Tool I: a structured interview questionnaire sheet about the vitiligo patients consist of two parts: part one:  socio-demographic, part two: medical data, Tool II: patient knowledge about vitiligo disease, Tool III: patient's attitude toward vitiligo disease and Tool IV: psychosocial status associated with Vitiligo. Results: 26.2% of the studied vitiligo patients have poor level of knowledge and 36.9% of them have fair and good knowledge level equally. 63.1% of the studied vitiligo patients have positive attitude and 36.9% have negative attitude, while 37.7% of them have poor psychological status. Conclusion: there is no significant relation between vitiligo disease and socio-demographic characterctices and there is no significant relation between socio-demographic and participants' knowledge. Recommendations: Designing and conducting a national level mass campaign of health education for the general public. Future studies should be planned to improve awareness and psychological status of vitiligo patients