Background: A totally implantable venous access device (TIVAD) provides patients with safe, effective, and long-term, convenient venous access (VA) for the administration of chemotherapy drugs (CD) .Aim: Evaluate the effect of implementing nursing guidelines (NG) on reducing late implanted portal catheter complications (LIPCC) among chemotherapy patients (CP) at Minia Oncology Center (MOC). Sampling: A purposive sampling of 70 adult patients connected to a portal catheter (PC). Tools: Two tools were used: The first tool, Patient Health Assessment (PHA), included two parts. First Part: Patient Demographic Data (PDD) Second Part: Patient's Medical Data (PMD). Second Tool: Portal Catheter Complications Observation Checklist (PCCOC).. The first part, General Assessment (GA), included four main complications. Second Part: Grading Scale for Monitoring Extravasation (GSME). Results More than half of the intervention group (IG) was female. There was a lower percentage of renal diseases and hypertension among the intervention group. It was noticed that systematic infection (SI) was present in 5.71 % of the intervention group while it was present in 8.27% of the control group (CG).  at the first observation, it was noticed that systematic infection percent increased among control group at the second and third observation (48.57 %, 74.28 %) respectively but it decreased among intervention group at second and third observations (11.4%) comparing with control group .It was noticed that there was a highly significant correlation between local infection (LI) and the number of chemotherapy sessions per week among intervention group. Conclusion: The current study findings concluded that adhering to nursing guidelines resulted in a lower percentage of late complications (LC) among the intervention group compared to the control group. Recommendations: Replication of the current study on a larger probability sample for different geographical locations in order to generalize the results.