Background: The nurses' work environment is getting global interest and concern because there is a growing consensus that identifying opportunities for improving working conditions in hospitals, adequate staffing, high-quality of patients care, and patient outcome. So the aim of this study was to assess relation of work environment on patients' outcomes at Minia oncology center. Research design: A descriptive correlational design was utilized in the current research. Setting: The research was conducted at Minia Oncology Center. Sample: Convenience sample (no.=66) of nurses as well as (no.=74) of patients. Tools of data collection: Two tools, the first tool was nurses' work environment scale and the second tool was patient outcomes scale. Results: the findings of the current research are (48.5%)of nurses have fair work environment, while (40.9%) of them have bad work environment. Moreover (89.2%)of patients have moderate level of patient's outcome, while (10.8%) of them have low level of patient's outcome. Conclusion: There were strongly positive correlation between nurse's practice work environment and patient's outcome (p= 0.002**). Recommendations: Provide in-service training program for studied nurses about nurse practice environment and patient outcomes.