The COVID-19 pandemic has highlighted the importance of infection control standard precautions, especially in healthcare settings. Nurses play a crucial role in implementing and ensuring adherence to these precautions to prevent the spread of the virus. Aim: assessment of nurses' performance in implementing infection control standard precautions in family health centers during the pandemic. Setting: Family Health Centers at Beni-Suef City. Sample: convenient sample of 124 nurses. Design: A descriptive exploratory study. Results: more than two-thirds of the studied sample was married, and more than one-quarter were in the 40-49 age. Nearly half had a technical nursing institute, followed by more than one quarter with a diploma. Overall, over one-third of the studied nurses had an average and good level of knowledge about COVID-19 and infection control measures. Also, Also, two-thirds of the studied sample had adequate practices, while one-third had inadequate practices. This study concluded there were still some nurses with low or high levels of knowledge and perceived barriers. Thus, it recommended providing accurate and up-to-date information about COVID-19 and Addressing barriers.