Background: Pin site infections are a common complication of external fixation that places a significant burden on the patient and healthcare system. The aim of the study: this study aimed  to evaluate the effect of using chlorhexidine solution on reducing pin site infection among patient with external fixation. Research design: Quasi experimental research design was utilized to fulfill the purpose of this study. Subjects: Purposive sample composed of sixty (30 study and 30 control) male& female patients Setting: The current study was carried out in Orthopedic department, Tools: Three tools were utilized to collect data, The first tool:  Structured interview Scio demographic and medical data questionnaire. The second tool: Grading of pin site infection. The third tool: Bacterial wound investigation sheet. Results:, It was the same percentage between studied sample regard overall score of infection criteria in two weeks, but control subjects have a progressive increase at 6th week reaching 90% among them were had pin site infection criteria while the study subjects recorded that  only a 17%. In the same weeks There are no statistical significance difference between studied sample regard infection criteria at 3rd and 4th week  while there highly statistical significance difference between them at 5th and 6th week P value= < 0.05. Conclusion: The study findings concluded that sterile dressing and using of chlorhexidine as alternative cleansing agent among study group who underwent external fixation was a positive effect on pin-site infections as compared to the control group. Recommendation: Hospitals should recommend using chlorhexidine solution as a cleansing agent for patients who underwent external fixation. Periodic training and educational programs about using chlorhexidine solution during dressing for prevention of pin site infection should be developed for the health team members especially the nursing staff.