Background: Hemodialysis (HD) stands as the most commonly treatment approaches within the field of dialysis. Sleep disturbances are more common problem among HD patients and affect patients' clinical outcomes. Progressive muscle relaxation is a nursing intervention that can be administered to hemodialysis patients to reduce these problems. Aim: Evaluate the effect of progressive muscle relaxation technique on sleep quality among hemodialysis patients. Research design: The aim of this study was achieved through utilizing a quasi-experimental research design. Sample: 60 adult patients with chronic renal failure who were receiving hemodialysis at Minia University Hospital for Urology and Nephrology were chosen as a purposeful sample. Tools: The data collection process involved the utilization of two tools; Structured Interview Questionnaire Sheet and Pittsburg Sleeping Quality Index (PSQI). Results: The global PSQI^,s mean score reduced immediately and post implementing the training program. Statistical significant differences were detected between the total PSQI mean score and age, residence, marital status, occupation and family income at the pretest. While at the immediate and posttests, statistical significant differences were observed between the total PSQI mean score age, marital status and educational level. Conclusion: It was concluded that progressive muscle relaxation effectively enhances the quality of sleep among patients receiving hemodialysis. Recommendation: Booster sessions could be conducted on intermittent periods after the first intervention to boost the long term effect of the training program.