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399689

Study of Epstein Barr Virus Infection in kidney Transplant Recipients: One Egyptian Center Study

Article

Last updated: 28 Dec 2024

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Tags

Clinical microbiology

Abstract

Background: Epstein–Barr virus (EBV) is the causative agent of infectious mononucleosis (IM). EBV infection is common in renal transplant recipients, due to the use of immunosuppressive drugs, and may lead to post-transplant lymphoproliferative disorders (PTLD). Thus, EBV accounts for high morbidity and mortality rates in solid organ transplant recipients. Objectives: The aim of this study was to examine the prevalence of EBV infection among Egyptian kidney transplant recipients and the relation between different immunosuppressive regimens, and EBV infection. Methodology: A total of one hundred kidney transplant recipients were included in this study (50 recent transplants and 50 late transplants). All cases were subjected to pre- and post-transplant evaluation, and post-operative immunosuppressive therapy. EBV infection was identified by serological testing for anti-EBV viral capsid antigen (VCA) IgG and IgM, and by molecular detection of Bacillus amyloliquefaciens H one (BamHI) region using conventional polymerase chain reaction (PCR). Results: BamHI region detection showed significant difference between the recent and late transplant groups (higher in late group) and was significantly associated with EBV VCA IgM; positive BamHI has 5.1 times higher odds of exhibiting positive IgM adjusted for the date of transplantation. Neither VCA IgM nor IgG were significantly different between the two studied groups. Conclusion: Despite the lack of association between EBV and immunosuppression drugs, hematological abnormalities, or graft function in this study, EBV monitoring in renal transplant recipients is required for early diagnosis of EBV infections and prevention of PTLD development. Serological diagnosis for EBV is of clinical importance as a simple, inexpensive tool for screening and follow-up of EBV infection. Molecular diagnosis of EBV by BamHI fragment detection had 5.1 times higher odds to exhibit positive IgM adjusted for the date of transplantation.

DOI

10.21608/ejmm.2024.344388.1402

Keywords

Epstein Barr Virus, Kidney transplantation, Molecular diagnosis

Authors

First Name

Mary

Last Name

Karras

MiddleName

S.

Affiliation

Clinical Pathology Department, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt

Email

mary@hotmail.com

City

-

Orcid

-

First Name

Noha

Last Name

El Mashad

MiddleName

-

Affiliation

Clinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

noha@hotmail.com

City

-

Orcid

-

First Name

Ayman

Last Name

Refaie

MiddleName

-

Affiliation

Nephrology Department, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt

Email

aymanr@hotmail.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Mofreh

MiddleName

-

Affiliation

Clinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

mefrehm@gmail.com

City

-

Orcid

-

First Name

Dina

Last Name

Badr

MiddleName

F.

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

dinaf@gmail.com

City

-

Orcid

-

First Name

Hazem

Last Name

Salah

MiddleName

H.

Affiliation

Medical Analysis fellow, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt

Email

hazzzeeeem@gmail.com

City

-

Orcid

-

First Name

Raghda

Last Name

Magar

MiddleName

W.

Affiliation

Clinical Pathology Department, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt

Email

magarw@gmail.com

City

-

Orcid

-

First Name

Maysaa

Last Name

Zaki

MiddleName

El Sayed

Affiliation

Clinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

may_s@mans.edu.eg

City

-

Orcid

-

First Name

Mohamed

Last Name

Rizk

MiddleName

A.

Affiliation

Clinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

aniesrizk@hotmail.com

City

-

Orcid

-

Volume

34

Article Issue

2

Related Issue

51523

Issue Date

2025-04-01

Receive Date

2024-12-14

Publish Date

2025-04-01

Print ISSN

1110-2179

Online ISSN

2537-0979

Link

https://ejmm.journals.ekb.eg/article_399689.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=399689

Order

399,689

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Study of Epstein Barr Virus Infection in kidney Transplant Recipients: One Egyptian Center Study

Details

Type

Article

Created At

28 Dec 2024