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Effect of Post COVID-19 hypoxia on Placenta of Pregnant Women: A possible Role of Hypoxia Inducible Factor-1α.

Article

Last updated: 28 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Clinical microbiology

Abstract

Background: The hypoxia-inducible factors (HIF) are considered master regulators of oxygen homeostasis and are oxygen level sensitive. Currently, there is no information regarding the expression of HIF-1α in pregnant women with COVID-19 infection and its potential involvement in the placentation of this condition. Objective: The current study aims to detect the expression of HIF-1α and possible molecular link between the expression of HIF-1α and PLGF. Methodology: A case-control study was conducted in a tertiary university hospital between January and September 2022. Placental tissue of post COVID-19 infected pregnant women (n= 34) and healthy control (n=16) were collected and processed for gene expression of HIF-1α and PLGF by Quantitative real-time PCR. Results: There was a statistically significant higher median level of HIF-1α among cases compared to controls (P<0.001). Moreover, there was a statistically significant higher median level of PLGF among cases compared to controls (P<0.001). There was statistically significant moderate positive correlation between HIF-1α and PLGF gene (r=0.636, P <0.001) among studied samples, however no statistically significant correlation between the two genes among cases and controls groups separately. Conclusion: the higher levels of HIF-1α and PLGF in the placentas of post COVID-infected pregnant women compared to normal pregnant women indicate that COVID-19 hypoxia did not affect the process of placentation. This is confirmed also by the positive correlation between

DOI

10.21608/ejmm.2024.343956.1399

Keywords

COVID-19, hypoxia, HIF-1α, PIGF

Authors

First Name

Fatma

Last Name

Abbas

MiddleName

Y. A.

Affiliation

Department of Physiology, Faculty of Medicine, Assiut University

Email

fatma_y@aun.edu.eg

City

Assuit

Orcid

-

First Name

Ebtihal

Last Name

Abd-Elaziz

MiddleName

A.

Affiliation

Department of Physiology, Faculty of Medicine, Assiut University

Email

ebtihal@aun.edu.eg

City

Assuit

Orcid

-

First Name

Fatma

Last Name

Helbawi

MiddleName

M.

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Assiut University

Email

fatmahelbawi@aun.edu.eg

City

Assuit

Orcid

-

First Name

Asmaa

Last Name

Abbas

MiddleName

Y. A.

Affiliation

Department of Histology and Cell Biology, Faculty of Medicine, Assiut University

Email

asmaayoussef@aun.edu.eg

City

Assuit

Orcid

-

First Name

Fatma

Last Name

Abd-Elsamea

MiddleName

S.

Affiliation

Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University

Email

fatmasayed@aun.edu.eg

City

Assuit

Orcid

-

First Name

Tohamy

Last Name

Tohamy

MiddleName

A.

Affiliation

Medical Research Center, Assiut University

Email

tohamy.anwar@scenise.edu.aun.eg

City

Assuit

Orcid

-

First Name

Ahmed

Last Name

Abbas

MiddleName

M.

Affiliation

Department of Obstetrics and Gynaecology, Faculty of Medicine, Assiut University

Email

ahmedabbas@aun.edu.eg

City

Assiut

Orcid

-

Volume

34

Article Issue

2

Related Issue

51523

Issue Date

2025-04-01

Receive Date

2024-12-12

Publish Date

2025-04-01

Print ISSN

1110-2179

Online ISSN

2537-0979

Link

https://ejmm.journals.ekb.eg/article_399437.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=399437

Order

399,437

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Effect of Post COVID-19 hypoxia on Placenta of Pregnant Women: A possible Role of Hypoxia Inducible Factor-1α.

Details

Type

Article

Created At

28 Dec 2024