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399028

Prevalence and Antimicrobial Susceptibility Profile of Gram-negative and Gram-positive Bacteria in a Tertiary Hospital: A Retrospective Study

Article

Last updated: 28 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Antimicrobial agents

Abstract

Background: To address the growing threat of drug-resistant organisms, it's crucial to establish effective stewardship programs. However, before doing so, it's vital to ensure access to evidence-based information on the local emergence of antibiotic resistance. Objective: The current study aims to determine the frequency of pathogens at one of Cairo University Hospitals and detect the antibiotic resistance profile of bacterial pathogens recovered from various sites of infections. Methodology: A three-year retrospective study was conducted (January 2020 and December 2022). We examined the information from the microbiology laboratory's Laboratory Data Manager, including the antimicrobial resistance profiles of pathogens isolated and identified from microbiological samples sent for routine culture. Results: Gram-negative isolates were more prevalent than Gram-positive ones. The most prevalent isolated pathogens were Klebsiella spp., Escherichia coli, Pseudomonas spp., and Coagulase-negative Staphylococci. Among Gram-negative organisms, more than 80% resistance was towards ceftriaxone, cefotaxime, ceftazidime, amoxicillin/clavulanic acid, and cefepime, while tigecycline showed the least resistance (19.15%). While, among Gram-positive organisms, vancomycin showed the least resistance (2.12%), and linezolid displayed minimal resistance (5.2%). Conclusions: Most of the investigated bacteria have become resistant to most antibiotics. This indicates an impending disaster that might threaten the future medical profession and needs extreme caution and continuous monitoring. Supporting local and national surveillance programs with ongoing monitoring of antimicrobial resistance patterns at the national and regional levels is a crucial step in the fight against emerging antimicrobial resistance. These findings imply that hospital resources should be the primary focus of efforts to reduce antibiotic resistance.

DOI

10.21608/ejmm.2024.340915.1389

Keywords

antibiotics, pathogens, prevalence, resistance

Authors

First Name

Amira

Last Name

Abbas

MiddleName

M.

Affiliation

Clinical and Chemical Pathology Faculty of Medicine, Cairo University, Cairo, Egypt

Email

amira.muhammad@kasralainy.edu.eg

City

-

Orcid

0000-0001-8738-3865

First Name

Reham

Last Name

Hamed

MiddleName

M. Raafat

Affiliation

Medical Microbiology and Immunology, Faculty of Medicine, Cairo University, Cairo, Egypt

Email

rehamraafat1986@yahoo.com

City

giza

Orcid

0000-0002-5526-2134

First Name

Marwa

Last Name

Elgendy

MiddleName

O.

Affiliation

Department of Clinical Pharmacy, Beni-Suef University Hospitals, Faculty of Medicine, Beni-Suef University, Beni Suef, Egypt; Department of Clinical Pharmacy, Faculty of Pharmacy, Nahda University (NUB), Beni-Suef, Egypt

Email

marwa.elgendy@nub.edu.eg

City

-

Orcid

0000-0002-5466-0552

First Name

Heba

Last Name

Abdel Aziz

MiddleName

S.

Affiliation

Clinical and Chemical Pathology Faculty of Medicine, Cairo University, Cairo, Egypt

Email

dr_heba87@cu.edu.eg

City

-

Orcid

0009-0004-2024-8748

Volume

34

Article Issue

2

Related Issue

51523

Issue Date

2025-04-01

Receive Date

2024-12-01

Publish Date

2025-04-01

Print ISSN

1110-2179

Online ISSN

2537-0979

Link

https://ejmm.journals.ekb.eg/article_399028.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=399028

Order

399,028

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Prevalence and Antimicrobial Susceptibility Profile of Gram-negative and Gram-positive Bacteria in a Tertiary Hospital: A Retrospective Study

Details

Type

Article

Created At

28 Dec 2024