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397287

Blood Levels of Programmed Cell Death Protein 1 and its ligand (PD-L1) as Predictors of Systemic Sclerosis Severity

Article

Last updated: 05 Jan 2025

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Subjects

-

Tags

Diagnostics

Abstract

Background: Programmed cell death protein 1 (PD-1) and PD-1 ligand (PD-L1), are key regulators of immune tolerance and are implicated in the pathogenesis of various autoimmune diseases. Systemic sclerosis (SSC) is a complex autoimmune condition characterized by widespread skin fibrosis, involvement of internal organs, and immune dysregulation leading to the production of autoantibodies. Objectives: The aim of this study was to evaluate the expression levels of PD-1 and PD-L1 on CD19+ B lymphocytes and CD3+CD8+ T lymphocytes in patients with SSC. We also aimed to assess the relationship between PD-1/PD-L1 expression and clinical parameters, laboratory findings, and the extent of skin sclerosis in SSC patients. Methodology: 45 patients diagnosed with SSC and 45 healthy controls were enrolled in this study. The expression of PD-1 and PD-L1 on CD19+ B cells and CD3+CD8+ T cells was evaluated using flow cytometry on peripheral blood samples. Results: The expression levels of PD-1 and PD-L1 were significantly elevated in both CD19+ B cells and CD3+CD8+ T cells in the SSC group in comparison to the control group (P = 0.001 for all comparisons). Additionally, strong positive correlations were observed between the expression of PD-1 and PD-L1 on both cell types and disease activity in the SCC group. Conclusions: The findings of this study suggest that PD-1 and PD-L1 may contribute to the modulation of disease severity in patients with SSC, highlighting their potential as biomarkers for disease activity.

DOI

10.21608/ejmm.2024.341047.1391

Keywords

Systemic sclerosis, Programmed Cell Death 1, programmed cell death ligand 1, B Lymphocytes, T lymphocytes

Authors

First Name

Heba

Last Name

Ahmed

MiddleName

-

Affiliation

Department of Clinical and Chemical Pathology - Faculty of Medicine, Sohag University, Egypt

Email

hebaalkady@ymail.com

City

-

Orcid

0000-0002-5680-8610

First Name

Ashraf

Last Name

Abdelwahab

MiddleName

-

Affiliation

Department of Dermatology, Venereology and Andrology - Faculty of Medicine, Sohag University, Egypt

Email

ashrafadva@yahoo.com

City

-

Orcid

0000-0002-1448-9957

First Name

Ebtesam

Last Name

Fayez

MiddleName

-

Affiliation

Department of Physical Medicine, Rheumatology and Rehabilitation - Faculty of Medicine, Sohag University, Egypt

Email

basmakhalaf@yahoo.com

City

-

Orcid

-

First Name

Amira

Last Name

Ahmed

MiddleName

-

Affiliation

Department of Medical Microbiology and Immunology - Faculty of Medicine, Sohag University, Egypt

Email

amiraesmail92@yahoo.com

City

-

Orcid

-

First Name

Nesma

Last Name

Ahmed

MiddleName

-

Affiliation

Department of Clinical and Chemical Pathology - Faculty of Medicine, Sohag University, Egypt

Email

dr.nesma84@yahoo.com

City

-

Orcid

0000-0002-0793-9606

Volume

34

Article Issue

2

Related Issue

51523

Issue Date

2025-04-01

Receive Date

2024-12-05

Publish Date

2025-04-01

Print ISSN

1110-2179

Online ISSN

2537-0979

Link

https://ejmm.journals.ekb.eg/article_397287.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=397287

Order

397,287

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Blood Levels of Programmed Cell Death Protein 1 and its ligand (PD-L1) as Predictors of Systemic Sclerosis Severity

Details

Type

Article

Created At

28 Dec 2024