Subjects
-Abstract
Background: The number of diseases caused by multidrug-resistant (MDR) bacteria is increasing across the world. The potential risk of untreatable MDR pathogenic bacteria has been looming since the beginning of the 21st century. In last years, numerous researches have been conducted and confirmed the antimicrobial activity of natural products. Bee venom (BV) is a potent natural substance that has antibacterial properties. The objective of the current study was to evaluate the antibacterial properties of bee venom alone or in combination with several traditional antibiotics. Methodology: Fourteen multi-drug resistant bacteria were isolated, molecularly identified using the 16s rRNA gene sequencing technique, and submitted to Genbank database to get accession numbers. The antibacterial efficacy of bee venom was determined using the disc diffusion method. Results: BV showed high effective action with concentration 0.35 µg/mL in combination with six groups of traditional antibiotics if compared to the antibiotics or bee venom alone. The addition of BV increased the effectiveness of the antibiotics and increased their antagonistic potency. Bee venom chemical composition was assessed using GC/MS giving Azoxystrobin and Tebuconazole as major compounds. In a conclusion, our study addressed the issue of antibiotic resistance by offering a natural substance as a supportive to pharmaceutical therapies.
DOI
10.21608/ejmm.2024.335658.1370
Keywords
MDR, Bee venom, Antimicrobials, Synergy, GC/MS
Authors
Affiliation
Department of Botany, Faculty of Science, Fayoum University
City
-Orcid
-Affiliation
Department of Botany, Faculty of Science, Fayoum University
Email
dr.shaimaafares888@gmail.com
City
-Orcid
-Affiliation
R&D Sector, EGYBLOOD-VACSERA
Email
i_elkalamawy@yahoo.com
City
-Orcid
-Affiliation
Department of Botany, Faculty of Science, Fayoum University
City
-Orcid
-Link
https://ejmm.journals.ekb.eg/article_393632.html
Detail API
https://ejmm.journals.ekb.eg/service?article_code=393632
Type
New and original researches in the field of Microbiology.
Publication Title
Egyptian Journal of Medical Microbiology
Publication Link
https://ejmm.journals.ekb.eg/
MainTitle
Synergistic Effect of the Bee Venom with Traditional Antibiotics on Multi-Drug Resistant Bacteria